GENETICS: Sweeping Through Toxoplasma

Sweeping through the Topic Space: Bad luck? Roll again!

Topic Models (TM) such as Latent Dirichlet Allocation (LDA) are increasingly used in Natural Language Processing applications. At this, the model parameters and the influence of randomized sampling and inference are rarely examined — usually, the recommendations from the original papers are adopted. In this paper, we examine the parameter space of LDA topic models with respect to the applicatio...

Pneumoviruses: Molecular Genetics and Reverse Genetics

Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...

Understanding Crohn's disease through genetics

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) with an eitologically complex pathology. Current evidence implicates dysregulation of the immune response to intestinal microflora and a parallel defect in maintenance of the epithelial barrier. The host genetic makeup is a key variable that underlies risk of disease, as highlighted by genomewide association studies (GWAS). This...

Improving Feed Efficiency Through Genetics

Cut Sweeping

This paper presents a light-weight sweeping method, similar to SATand BDD-sweeping. Performance are on the order of 10x to 100x faster than SAT-sweeping for large designs, while achieving about 50-90% of the reductions.